ABOUT AUTHORS
BHANDARI SALONI *, KISHNANI KHUSHBOO, RATHORE KAMAL SINGH
BN College of Pharmacy, Udaipur-Raj. 313001
salonibhandari1996.sb@gmail.com
ABSTRACT
Liposomes are concentric bilayer vesicles, which were first developed by Bangham and his colleagues in 1961. They are highly efficient having high drug entrapment capacity. Due to their size, hydrophobic and lipophilic character they are most widely used vehicles for drug delivery. The main aim of this drug delivery system is to target the drug directly to the site of action in order to prolong and enhance the drug effect. Liposomes are biocompatible and stable and are able to entrap both hydrophilic and lipophilic drug within its compartment. The size range varies from 0.05-5.0µ in diameter. Various convectional techniques used for liposomal preparation and size reduction are mechanical dispersion methods, solvent dispersion methods and detergent removal method. Due to difference in method of preparation and composition of lipids, liposomes can be characterized according to size, charge, lamellarity etc. This article provide an overview of liposomes, advantages, disadvantages, mechanism of action, classification, structural composition, preparation as well as evaluation parameters, applications and future aspects.
