AstraZeneca and Amgen’s Tezepelumab Demonstrates 86% Reduction in Exacerbations in Patients with Asthma and Nasal Polyps

September 6, 2021 Auto Bot Amgen, Asthma, AstraZeneca, Clinical Trials, Nasal Polyps, Tezepelumab 0

Shots:

  • The P-III NAVIGATOR study involves assessing Tezepelumab + SOC vs PBO +SOC in adults (18–80yrs.old) and adolescents (12–17yrs. old) with severe, uncontrolled asthma. The study showed improvements in lung function and nasal polyp symptoms
  • The pre-specified exploratory analysis evaluated the effect of tezepelumab in NAVIGATOR patients with/ out reported nasal polyps (NP+ or NP−) in the past 2yrs. The analysis showed an 86% reduction in the AAER in NP+ patients & 52% in NP− patients over 52wks.
  • Other results include an increase in pre-bronchodilator FEV1 (0.20 L vs 0.13 L), 9.6 points reduction in SNOT-22 score in NP+ patients (21.5 vs 19.0), The results were published at ERS 2021

Click here to­ read full press release/ article | Ref: AstraZeneca | Image: Business Standard

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