AstraZeneca Reports P-III Trial (DUO-E) Results of Imfinzi (durvalumab) + Lynparza (olaparib) for  Advanced Endometrial Cancer

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The P-III trial evaluating Imfinzi + Pt-based CT, followed by Imfinzi with Lynparza or Imfinzi alone as maintenance therapy vs Pt-based CT alone in 699 patients at 253 study locations across 22 countries incl. the US, EU, South America & Asia
The results showed a significant & clinical improvement in PFS, greater benefits were seen with the combination of Lynparza + Imfinzi as maintenance treatment while OS data were immature & favorable trends were reported for both a treatment regimen
The safety & tolerability profile was consistent with prior clinical trials & the known profile of the individual’s therapies. The company will discuss the results with the regulatory authorities

Ref: AstraZeneca | Image: AstraZeneca 

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