Open Source “Wikipedia” for Drug Discovery

By Kambiz Shekdar, Ph.D. Open source drug discovery was proposed in the past in connection with third-world diseases like tuberculosis and malaria, but it is in the context of first-world indications where it is needed most. Despite untold investment by numerous pharmaceutical companies, FDA-approved drugs that target critical brain functions and conditions like anxiety, depression, and sedation continue to present severe and unpredictable side effects, including suicidal ideation. Open source drug discovery will allow more efficient, predicable, and cost-effective development of drugs that work as advertised, with fewer side effects. In 2003 the Human Genome Project provided the first atlas

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