Vertex Collaborates with Mammoth Biosciences to Develop In Vivo Gene-Editing Therapies for Genetic Diseases

Shots:

  • Mammoth to receive $41M up front, $650M as future payments based upon the achievement of prespecified research, development & commercial milestones across 2 programs & is eligible to receive royalties on sales of any products
  • The collaboration will bolster Vertex’s cell and genetic therapies capabilities with the addition of Mammoth’s ultra-small CRISPR systems to develop in vivo genome editing therapies for patients with serious diseases
  • Mammoth’s CRISPR platform consists of a proprietary toolbox of novel ultra-compact Cas enzymes including Cas14 and Casɸ. The platform is designed to facilitate advanced delivery of in vivo gene-editing for genetic diseases

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