The Mirror World
Now this is a paper that’ll make your head spin. It’s from the Zhu group at Tsinghua University, and the head-spinning will be both because […]
Chemical Biology
A Fifty-Year-Old Cancer Drug Doesn’t Do What You Think
5-fluorouracil (5-FU) has been around a long time now (over fifty years), and it’s a standard oncology drug (particularly in colorectal treatment regimes). But try […]
Chose Your Controls Wisely
I’ve been meaning to write about this paper (open access) on some problems with chemical probes, and now’s a good time. There was a well-known […]
Med-Chem Should Be Larger Than It Is
I’m really glad to see this Perspective article in the Journal of Medicinal Chemistry, not least because it hits on a theme that I emphasize […]
Tie Me Proteins All Down, Sport
There are a lot of slick ideas in molecular and chemical biology that depend on immobilizing proteins or small molecules onto solid supports. Consider affinity […]
Watching mRNA Do Its Thing, In Living Cells
This is a nice chemical biology paper that hits on a hot topic of the day: the uptake and function of mRNA when administered to […]
Mysteries in Human RNA
Let’s put this one in the category of “more things that we didn’t know about human biology”. We’ve known for some time now about ribozymes […]
Comprehensive Covalent Probe Time
I really enjoyed this new paper on ChemRxiv, a Munich/Michigan/Berkeley collaboration on reactive covalent groups and their profile across different proteins. There have been a […]
