Incyte to Acquire Escient Pharmaceuticals and its MRGPR Antagonist Assets

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Incyte to acquire Escient Pharmaceuticals for $750 M plus Escient’s remaining net cash at closing of transaction (based on customary adjustments). Closing of acquisition is anticipated in Q3’24
Acquisition will enhance Incyte’s R&D activities in Inflammation and Autoimmunity (IAI) by addition of Escient’s MRGPR antagonists, EP262 and EP547; possible launch begins in 2029
Moreover, EP262 in the P-I study showed safety and tolerability at all doses tested with no AEs & SAEs, vital signs, or ECG parameters, whereas TEAEs were mild having incidence lesser than PBO (33.3% vs. 62.5%) and did not rise with change in dose

Ref: Incyte | Image: Incyte

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