The first patient has been dosed in a P-IIa clinical trial evaluating the safety, tolerability, and efficacy of two doses of TLC-3595 (selective inhibitor of acetyl-CoA carboxylase 2) in 50 overweight or obese patients with insulin resistance incl. T2D treated with glucose-lowering therapies
The 1EPs of the trial are improvement in insulin sensitivity based on results from OGTT after 4wks. of therapy while additional exploratory EPs incl. biomarker of glycemic control, fatty acid oxidation, lipids, and MRI/MRS-based assessments of muscle and liver fat
OrsoBio obtained an exclusive global right in 2022 to an ACC2 inhibitor program with lead compound TLC-3595 from Shionogi & Co., Ltd
Ref: Businesswire | Image: OrsoBio
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