Treatment with a molecule known as A485 can quickly and temporarily increase levels of white blood cells, a critical part of the body’s immune system, an effect that is difficult to deliver with currently available pharmaceuticals, a new Yale study finds. In an experiment, the researchers found that exposure to the molecule in mice caused white blood cells to mobilize from the bone marrow, a response that could inform future treatment for patients who need a boost in immune activity, the researchers say. The findings were reported Jan. 31 in the journal Immunity.
