Allogene Reports Results of ALLO-501 and ALLO-501A in P-I Studies for Relapsed/Refractory Non-Hodgkin Lymphoma

May 20, 2021 Auto Bot Clinical Trials, non-Hodgkin lymphoma, Refractory, Relapsed 0

Shots:

  • The P-I ALPHA study of ALLO-501 produced durable CR with the longest ongoing CR @15mos. in both LBCL and FL. ORR (75%) and CR (50%) across histologies in CAR T naïve patients, on par with data from pivotal trials of autologous CAR T therapies
  • The APLHA-2 data demonstrated comparable efficacy & safety for ALLO-501A relative to ALLO-501. The consolidation dosing was well tolerated and showed early promise with 4 patients converting from PR to CR following the second dose of ALLO-501 or ALLO-501A
  • The data will be presented at ASCO 2021. The company plan to initiate the pivotal trial of ALLO-501A in late 2021

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