cbaker_admin
Thu, 07/23/2020 – 15:30
Subclinical hypothyroidism mediates poor outcomes in patients with acute myocardial infarction (MI), but U.K. researchers wondered if administration of levothyroxine might curb these risks. Specifically, they hypothesized that levothyroxine would improve left ventricular function in this patient population. To test their theory, they recruited 95 patients for a randomized trial. Participants were assigned in a 1:1 ratio either to the study drug or to placebo, both to be administered on a daily basis for 1 year. The main outcome, measured in 85 enrollees, was mean left ventricular ejection fraction at the end of the treatment period. For the intervention group, readings improved from 51.3% at baseline to 53.8% at 52 weeks; while the change was from 54% to 56.1% in the controls. There were six secondary endpoints, with no significant between-group differences apparent. Additionally, the rate of cardiovascular adverse events was comparable between the two treatment arms. The evidence, study authors concluded, does not support treatment of subclinical hypothyroidism in patients with acute MI.
