Incyte and Novartis Publish Results of Jakafi (ruxolitinib) in P-III REACH3 Study to Treat Chronic Graft-Versus-Host Disease in NEJM

July 15, 2021 Auto Bot Clinical Trials 0

Shots:

  • The P-III REACH3 study involves the safety & efficacy of ruxolitinib vs BAT in patients with steroid-refractory chronic GVHD
  • The study showed improvements in 1EPs i.e ORR (49.7% vs 25.6%) & BOR (76.4% vs 60.4%) @24wks. & also showed the improvements in 2EPs i.e patients achieved longer FFS than BAT, m-FFS (not reached vs. 5.7mos.); improvements in self-reported symptoms (24.2% vs 11.0%), no new safety signals were observed
  • The new subgroup analysis showed higher ORR for Jakavi-treated patients regardless of individual organs involved at baseline. Regulatory submissions are currently ongoing for acute & chronic GvHD outside the US

Click here to read full press release/ article | Ref: Novartis | Image: Clinical Trials Arena

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