Merck KGaA Sign an Exclusive Worldwide License Agreement with Debiopharm for Xevinapant

Shots:

  • Debiopharm to receive $226M up front, ~$853.7M as regulatory and commercial milestones along with royalties. The transaction is expected to close in early Q2’21
  • Merck KGaA get an exclusive right to develop and commercialize xevinapant globally, including in the US and will co-fund the ongoing P-III TrilynX study that involves assessing Xevinapant vs PBO in 700 patients in combination with CRT in cisplatin-eligible patients with high-risk LA SCCHN
  • Xevinapant has received the FDA’s BTD in Feb 2020, based on the P- II results that showed xevinapant + CT reduced risk of death by 51% vs SOC in this patient with high-risk LA SCCHN

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