Neanderthal-specific Variants in Sodium Ion Channel Gene Associated with Sensitivity to Pain in Modern Humans

By Kevin E. Noonan — Over the past decade, genetic archeology has revealed two branches of the human family tree, one known since the 19th Century (the Neanderthals) and the other more recently discovered (the Denisovans, an Asian relative of the Neanderthal population). These populations evolved without genetic intermingling with Homo sapiens sapiens for about 500,000 years, which resulted in the accumulation of genetic variants specific for these populations. But the migration of modern human populations out of Africa and throughout the world resulted in interbreeding between humans and Neanderthals or Denisovans about 60,00-40,000 years ago, and as a result…