Merck Reports Results of Keytruda (pembrolizumab) in P-III KEYNOTE-826 Trial as 1L Treatment for Cervical Cancer

September 20, 2021 Auto Bot cervical cancer, Clinical Trials, KEYTRUDA, Merck, P-III, pembrolizumab 0

Shots:

  • The P-III KEYNOTE-826 trial evaluates Merck’s Keytruda (200mg, IV, q3w for up to 35 cycles) + Pt-based CT vs PBO + CT with/out bevacizumab in 617 patients aged b/w 22- 82yrs. with persistent, recurrent, or metastatic cervical cancer
  • The results showed a 33% reduction in the risk of death; m-OS (24.4 vs 16.5mos.), m-PFS (10.4 & 8.2 mos.); ORR (65.9% & 50.8%); m-DoR (18.0 & 10.4mos.), TRAEs grade ≥3 (68.4% & 64.1%), discontinuation of the treatment due to TRAEs (31.3% & 3.3%) in patients with combination therapy. The results were consistent with/out bevacizumab use
  • Keytruda is an anti- PD-1 therapy that increases the ability of the body’s immune system to help detect and fight tumor cells

Click here to­ read full press release/ article | Ref: Merck | Image: The Conversation

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