Moderna Report Results of mRNA-4157 + Keytruda in Interim P-l Study for HNSCC and MSS-CRC

November 12, 2020 Auto Bot Clinical Trials, Moderna, pembrolizumab, Report, results 0

Shots:

  • The expansion cohort of P-l study involves assessing of mRNA-4157 + Keytruda (pembrolizumab) vs Keytruda monothx. in 10 patients with HPV (-) HNSCC and 17 patients with MSS-CRC, presented at the SITC 2020.
  • Results: in the HPV(-) HNSCC group, ORR (50% vs 14.6%) with 2 patients achieving CR & 3 patients achieving PR; mPFS (9.8 vs 2.0 mos.); DCR (90%); median duration of response has not been reached. No responses were observed in the MSS-CRC group of patients
  • The company continues to recruit in HPV(-) HNSCC cohort and has decided to expand the size of the current cohort based on the interim data reported

Click here­ to­ read full press release/ article | Ref: Businesswire | Image: Stat

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