Molecular Mechanism for (In)Famous Warburg Effect in Cancer Elucidated

By Kevin E. Noonan — Cancer, the “Emperor of All Maladies” as it has been termed, has been studied for millennia. President Nixon’s “War on Cancer” resulted in slow but steady progress, aided by the biotechnology revolution, the development of monoclonal antibodies (see Herceptin®) and more recent developments in immunological interventions like CAR-T cells (see “Global CAR-T Cell Therapy Market (2021 to 2027) – Size, Forecasts, Trials and Trends -ResearchAndMarkets.com”). But the basis for many characteristics of cancer biology remain elusive, including what is classically termed the Warburg effect, i.e., the tendency of cancer cells to be dependent upon aerobic…